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Effect of feed and environmental enrichment on development of stereotypic wire-gnawing in laboratory mice

By H. Wurbel, R. Chapman, C. Rutland

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Abstract

At 21 days of age, 16 pairs of male ICR laboratory mice were weaned and allocated to 4 treatment groups in a 2 x 2 factorial design matched for genetic background (litter) and body weight. Factor one was the hardness of feed pellets with a significant 2.5-fold difference between soft and hard feed. Factor two was the environment, with half the mice being kept in barren standard cages, while the other half were additionally provided with a cardboard tube. Subjects were videotaped during the full 12-h dark period on 3 occasions: 3 days after weaning, when stereotypies start to develop (24 days), at an early stage of stereotypy development (34 days), and when adult with fully established stereotypies (80 days). Since feed hardness had no effect on time spent feeding, the absence of an effect of the feeding treatment on stereotypic wire-gnawing remains inconclusive with respect to the role of feeding motivation in the development of this stereotypy. The interaction between the development of feeding and wire-gnawing, respectively, does not, however, suggest a strong relationship. In contrast, enrichment reduced stereotypic wire-gnawing in adults by 40% (F=4.47, df=1.26, p<0.05), presumably as a consequence of the cover provided by the cardboard tubes. This is substantiated by observations that the tubes were used as a place to retreat upon disturbance as well as for resting. As a consequence, when fully adult the mice showed more resting (F=6.46, df=1.26, p<0.05) and less grooming (F=9.79, df=1.26, p<0.01) in cages containing them, suggesting that mice with access to a cardboard tube (and hence shelter) perceived a greater level of security in these cages. Cardboard tubes provide a simple means of environmental enrichment to reduce the development of abnormal behaviour in laboratory mice and may thus be beneficial in terms of their well-being.

Date 1998
Publication Title Applied Animal Behaviour Science
Volume 60
Issue 1
Pages 69-81
ISBN/ISSN 0168-1591
Language English
Author Address Department of Clinical Veterinary Science, Division of Animal Health and Husbandry, University of Bristol, Langford House, Langford, Bristol BS18 7DU, UK.
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Tags
  1. Animal behavior
  2. Animal nutrition
  3. Animal rights
  4. Animal welfare
  5. Development
  6. Eating habits
  7. Enrichment
  8. Feeding behavior
  9. Feeds
  10. Hardness
  11. Housing
  12. Mammals
  13. Mice
  14. morphogenesis
  15. motivation
  16. ontogeny
  17. peer-reviewed
  18. Rodents
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  1. peer-reviewed