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Evaluation of pharmacokinetics and efficacy of ivermectin following oral administration in dogs against experimental infection of Ctenocephalides felis felis and Rhipicephalus sanguineus

By V. S. Magalhaes, Y. P. Cid, T. P. Ferreira, D. M. V. Medeiros, L. C. de S. O. Batista, T. R. Correia, A. L. M. Albert, F. B. Scott

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Abstract

With the increasing number of pets in home the human-animal relationship is increasingly close and care about control disease growing. Ivermectin (IVM) is frequently used because its proven safety. IVM is recommended for the treatment of demodectic scabies and prevention of heartworm in dogs, but informally is extremely used to control of Ctenocephalides felis felis and Rhipicephalus sanguineus. The aim of this study is evaluate the use of IVM in dogs, by the oral route at 0.6 g/kg dose, against experimental infection of these parasites using the construction of the plasma concentration curve and efficacy study. A IVM quantification method in canine plasma using HPLC-FL was developed and validated based on RE n°899/03 ANVISA. The samples collected during the efficacy test was analyzed by this validated method and prove Cmax of 350 ng/mL at 4 h (tmax) and AUC of 8411 ng/h/mL. Spite of formulation have shown good absorption, the highest efficiency values found for Rhipcephalus sanguineus and Ctenocephalides felis felis were very low, 35% and 67% respectively, demonstrating this not be the most appropriate treatment for the control of these parasites.

Publication Title Veterinary Parasitology
Volume 228
Pages 167-171
ISBN/ISSN 0304-4017
DOI 10.1016/j.vetpar.2016.09.004
Language English
Author Address Animal Parasitology Department, Federal Rural University of Rio de Janeiro (UFRRJ), BR 465, Km. 7, 23897-000 Seropedica, RJ, Brazil.vsmagalhaes@gmail.com vsmagalhaes@ufrrj.br
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Tags
  1. Administration
  2. Anesthesia
  3. Animals
  4. Anthelmintics
  5. Arthropods
  6. Blood
  7. Canidae
  8. Canine
  9. Carnivores
  10. Chemicals
  11. Control
  12. Dogs
  13. Ecology
  14. Efficacy
  15. Experimentation
  16. Fleas
  17. heartworm
  18. Infectious diseases
  19. Insects
  20. Invertebrates
  21. Mammals
  22. Metastigmata
  23. Mites
  24. nematodes
  25. Parasites
  26. Parasitic diseases
  27. Parasitology
  28. Pesticides and Drugs
  29. Pets and companion animals
  30. pharmacokinetics
  31. Pharmacology & Pharmacy
  32. Quantitative research
  33. roundworm
  34. safety
  35. scabies
  36. Science
  37. spiders
  38. Techniques
  39. therapy
  40. Ticks
  41. vertebrates
  42. Veterinary pharmacology
  43. Veterinary sciences
  44. Zoology