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Treatment of separation anxiety in dogs with clomipramine: results from a prospective, randomized, double-blind, placebo-controlled, parallel-group, multicenter clinical trial

By J. N. King, B. S. Simpson, K. L. Overall, D. Appleby, P. Pageat, C. Ross, J. P. Chaurand, S. Heath, C. Beata, A. B. Weiss, G. Muller, T. Paris, B. G. Bataille, J. Parker, S. Petit, J. Wren

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Abstract

The efficacy and tolerability of clomipramine in the treatment of separation anxiety in dogs was tested in a prospective, randomized, double-blind, placebo-controlled, parallel-group, international multicentre clinical trial. For a diagnosis of separation anxiety, dogs had to exhibit at least one of the following signs in the absence of their owner: destruction, defaecation, urination and/or vocalization, as well as the behaviour suggestive of "hyper-attachment" to their owner. 95 dogs were randomized to receive 1 of the 3 treatments for 2-3 months: "standard-dose" clomipramine (1 to pramine group were rated improved for the signs destruction, defaecation and urination, and in an owner's global assessment of the dog's overall behaviour. However, there were no significant differences at any time point between the standard dose and the placebo groups in the sign vocalization. The low-dose clomipramine group produced no significant effect when compared with placebo. Mild and transient vomiting was noted as a side effect of clomipramine in a small number of dogs. It is concluded that addition of standard-dose (1 to

Date 2000
Publication Title Applied Animal Behaviour Science
Volume 67
Issue 4
Pages 255-275
ISBN/ISSN 0168-1591
DOI 10.1016/S0168-1591(99)00127-6
Language English
Author Address Novartis Animal Health, Werk Rosental, CH-4002, Basel, Switzerland.
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Tags
  1. Adverse effects
  2. Adverse reactions
  3. Animal behavior
  4. Animal diseases
  5. Animal welfare
  6. Antidepressants
  7. Anxiety
  8. Behavior and behavior mechanisms
  9. Carnivores
  10. Chemotherapy
  11. Deviant behavior
  12. Dogs
  13. Drug therapy
  14. Mammals
  15. neuroactive drugs
  16. neurotropic drugs
  17. Pets and companion animals
  18. Pharmacology & Pharmacy
  19. randomized trials
  20. Separation anxiety
  21. treatment
  22. Veterinary medicine