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The involvement of dopamine (DA) and serotonin (5-HT) in stress-induced stereotypies in bank voles ( Clethrionomys glareolus )

By B. Schoenecker, K. E. Heller

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Abstract

In order to clarify the dependency of stress-induced stereotypies on dopamine (DA) and serotonin (5-HT) functioning, undisturbed and acutely stressed stereotyping bank voles were treated during 3 weeks with the commonly used human atypical neurolepticum clozapine and the SSRI antidepressant citalopram. Clozapine blocks DA receptors (D sub (4)) and acts as a partial 5-HT antagonist (5-HT sub (2) receptors), while citalopram increases 5-HT transmitter activity. Levels of stereotypies were quantified under undisturbed conditions during the treatment period and immediately after the acute stress of handling and injections. It was demonstrated that stereotypies are markedly increased after acute stress and that citalopram effectively mitigates this stress effect. Stereotypies under undisturbed conditions were left unaffected by both clozapine and citalopram treatments. It is suggested that stress-induced increases in stereotypies are more dependent on 5-HT than DA functioning.

Date 2001
Publication Title Applied Animal Behaviour Science
Volume 73
Issue 4
Pages 311-319
ISBN/ISSN 0168-1591
DOI 10.1016/S0168-1591(01)00143-5
Language English
Author Address Zoological Institute, University of Copenhagen, Tagensvej 16, DK-2200 Copenhagen N, Denmark.
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Tags
  1. Animal models
  2. Antidepressants
  3. Behavior and behavior mechanisms
  4. Denmark
  5. Developed countries
  6. Diseases
  7. Dopamine
  8. Europe
  9. Human behavior
  10. Mammals
  11. Mental disorders
  12. Mental illness
  13. OECD countries
  14. peer-reviewed
  15. pharmaceuticals
  16. Primates
  17. psychiatric disorders
  18. Rodents
  19. Scandinavia
  20. serotonin
  21. Stress
  22. tranquilizers
  23. voles
Badges
  1. peer-reviewed