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Genetically modified laboratory animals - what welfare problems do they face?

By M. Buehr, P. J. Hjorth, A. K. Hansen, P. Sandoe

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Abstract

In this article, we respond to public concern expressed about the welfare of genetically modified (GM) non-human animals. As a contribution to the debate on this subject, we attempt in this article to determine in what situations the practice of genetic modification in rodents may generate significant welfare problems. After a brief discussion of the principles of animal welfare, we focus on the problem of animal suffering and review some types of gene modifications likely to cause predictable welfare problems. In this article, we also consider suffering that may be involved in the process of generating GM animals. Finally, we discuss the role of GM animals in attempts to reduce, replace, and refine the use of animals in research.

Publication Title Journal of Applied Animal Welfare Science
Volume 6
Issue 4
Pages 319-338
ISBN/ISSN 1088-8705
Publisher Taylor & Francis
DOI 10.1207/s15327604jaws0604_6
Language English
Author Address Center for Bioethics and Risk Assessment, Department of Molecular Biology, University of Aarhus, C. F. Mollers Alle Building 130, DK-8000 Arhus C, Denmark.ph@mb.au.dk
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Tags
  1. Animal genetics
  2. Animal rights
  3. Animals
  4. Animal welfare
  5. Diseases
  6. Genetically engineered animals
  7. Genetically engineered organisms
  8. Genetically modified animals
  9. Genetically modified organisms
  10. Genetic engineering
  11. Genetic manipulation
  12. Genetics
  13. Genotypes
  14. Laboratory and experimental animals
  15. Laboratory animal science
  16. Mammals
  17. mutations
  18. peer-reviewed
  19. phenotypes
  20. Rodents
  21. transgenics
  22. vertebrates
Badges
  1. peer-reviewed