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Urinary corticosterone levels in mice in response to intraperitoneal injections with saline

By M. K. Meijer, A. G. Lemmens, B. F. M. van Zutphen, V. Baumans

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Abstract

The concept of refinement is an important issue in the field of laboratory animal science. Refinement-based research aims to improve animal welfare, to increase the reliability of experimental outcome, and to diminish variation. In search of refinement of experimental techniques, this study investigated whether urinary corticosterone can be used as a noninvasive measure of acute stress in mice.

Publication Title Journal of Applied Animal Welfare Science
Volume 8
Issue 4
Pages 279-283
ISBN/ISSN 1088-8705
Publisher Taylor & Francis
DOI 10.1207/s15327604jaws0804_4
Language English
Author Address Department of Animals, Science, and Society, Utrecht University, P.O. Box 80166, 3508 TD Utrecht, Netherlands.m.k.meijer@vet.uu.nl
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Tags
  1. Animal experimentation
  2. Animal physiology
  3. Animal research
  4. Animal rights
  5. Animals
  6. Animal welfare
  7. Corticosteroids
  8. Injection
  9. Laboratory and experimental animals
  10. Laboratory animal science
  11. Mammals
  12. Mice
  13. peer-reviewed
  14. Rodents
  15. Stress
  16. Stress response
  17. Techniques
  18. urine
  19. vertebrates
Badges
  1. peer-reviewed