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Blood collection procedure of laboratory primates: a neglected variable in biomedical research

By V. Reinhardt, A. Reinhardt

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Abstract

A survey of 75 biomedical articles dealing with stress-dependent blood parameters ni caged primates revealed that the conditions under which blood collection occurred were in most cases described either not at all or so haphazardly that it would be impossible to determine if humane handling procedures were used and basic principles of scientific evidence not only that stress-sensitive research data are influenced by traditional blood sampling procedures, but also those data-biasing effect can be avoided. If dependent variables of the blood collection procedure are not controlled, data variability will increase, automatically increasing the number of animals needed for statistical analysis. For ethical and scientific reasons, it was recommended that editors of biomedical journals require authors to provide sufficient information of the blood collection, and, when applicable, the sedative injection as a procedure to ensure that the experiment was done with the smallest number of animals possible to achieve statistical significance and that the investigation can be replicated reliably in another laboratory and the research data interpreted with reasonable accuracy.

Publication Title Journal of Applied Animal Welfare Science
Volume 3
Issue 4
Pages 321-333
ISBN/ISSN 1088-8705
Publisher Taylor & Francis
DOI 10.1207/S15327604JAWS0304_4
Language English
Author Address Animal Welfare Institute, 15507 Lakeside Drive, Weed, CA 96094, USA.
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Tags
  1. Animals
  2. Animal welfare
  3. Blood
  4. Ethics
  5. Laboratory animal science
  6. Mammals
  7. Monkeys
  8. peer-reviewed
  9. Primates
  10. sampling
  11. statistical analysis
  12. Techniques
  13. tranquilizers
  14. vertebrates
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  1. peer-reviewed