A survey of 75 biomedical articles dealing with stress-dependent blood parameters ni caged primates revealed that the conditions under which blood collection occurred were in most cases described either not at all or so haphazardly that it would be impossible to determine if humane handling procedures were used and basic principles of scientific evidence not only that stress-sensitive research data are influenced by traditional blood sampling procedures, but also those data-biasing effect can be avoided. If dependent variables of the blood collection procedure are not controlled, data variability will increase, automatically increasing the number of animals needed for statistical analysis. For ethical and scientific reasons, it was recommended that editors of biomedical journals require authors to provide sufficient information of the blood collection, and, when applicable, the sedative injection as a procedure to ensure that the experiment was done with the smallest number of animals possible to achieve statistical significance and that the investigation can be replicated reliably in another laboratory and the research data interpreted with reasonable accuracy.
|Publication Title||Journal of Applied Animal Welfare Science|
|Publisher||Taylor & Francis|
|Author Address||Animal Welfare Institute, 15507 Lakeside Drive, Weed, CA 96094, USA.|
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