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A bond beyond friendship: dog, man, and comparative oncology

By A. Borgatti, P. Buracco

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Abstract

"Comparative oncology" refers to a discipline that integrates spontaneously-arising tumors in veterinary patients with studies of cancer biology, progression, and therapy. Unlike artificially-induced tumors in rodents whose "instantaneous" development does not reflect the pathogenesis of human cancers, naturally-occurring tumors in pet dogs and humans share numerous features such as genetic characteristics, histopathological appearance, biological behavior, molecular targets and response to conventional cancer therapy. These similarities, along with the high number of dogs diagnosed with cancer each year, suggest that studying dogs as models for humans is likely to provide important insights towards a better understanding of the biology of cancer in both species. Additionally, studies of experimental treatments in dogs can help identify the therapeutic approaches most deserving of further investigation and guide the selection of tumor types most likely to benefit from novel treatments. The purpose of the manuscript presented herein is to provide the reader with an understanding of the concept of "comparative oncology" as well as its purpose and potential for the future of cancer research.

Date 2009
Publication Title Veterinaria (Cremona)
Volume 23
Issue 2
Pages 9-25
ISBN/ISSN 0394-3151
Language Italian
Author Address Department of Veterinary Clinical Sciences, Veterinary Medical Center, University of Minnesota, College of Veterinary Medicine, St. Paul, Minnesota, USA.
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Tags
  1. Animal diseases
  2. Animal models
  3. Cancer
  4. Chemotherapy
  5. Diagnosis
  6. Dogs
  7. Drug therapy
  8. Mammals
  9. pathogens
  10. Pets and companion animals
  11. Primates
  12. Research
  13. Studies