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Combined exposure to dog and indoor pollution: incident asthma in a high-risk birth cohort

By C. Carlsten, M. Brauer, H. Dimich-Ward, A. Dybuncio, A. B. Becker, M. Chan-Yeung

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Abstract

The impact of single exposures on asthma development is better understood than the effect of multiple exposures. The objective of the present study was to evaluate the effect of combined early exposure to dog allergen (Can-f1) plus indoor nitrogen dioxide (NO2) or environmental tobacco smoke (ETS) on asthma and bronchial hyperreactivity (BHR) in a high-risk birth cohort. We also aimed to assess atopy's impact on the effects of these exposures.

Peri-birth ETS exposure was measured using cord blood cotinine (CCot). During year 1, atopy, NO2, Can-f1, and urinary cotinine (UCot) were measured. At 7 yrs of age, 380 children were assessed for asthma and BHR. Exposure effects were determined using stepwise multiple linear regression.

Co-exposure to elevated Can-f1 and NO2, or Can-f1 and ETS (CCot), increased risk for asthma, relative to having neither such exposure (OR 4.8 (95% CI 1.1–21.5) and 2.7 (1.1–7.1), respectively); similar risks resulted when substituting dog ownership for allergen. Atopy increased asthma and BHR risk associated with several exposures; notably, atopy with elevated UCot, relative to atopy without such exposure, increased risk of BHR (OR 3.1 (95% CI 1.1–8.6)).

In a high-risk birth cohort, early co-exposure to Can-f1 and NO2 or ETS increased the risk of incident asthma. Atopy increased the risk of asthma and BHR associated with ETS.        

Date 2011
Publication Title European respiratory journal
Volume 37
Issue 2
Pages 324-30
ISBN/ISSN 1399-3003 (Electronic)0903-1936 (Linking)
DOI 10.1183/09031936.00187609
URL https://erj.ersjournals.com/content/37/2/324
Language English
Author Address Vancouver General Hospital (The Lung Center), Vancouver, Canada. chris.carlsten@vch.ca
Additional Language English
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Tags
  1. Air
  2. Allergy
  3. Asthma
  4. Children
  5. Cohort Studies
  6. Dogs
  7. Environment
  8. Females
  9. Fetus
  10. Humans
  11. Hyperactivity
  12. Incidence
  13. Infants
  14. Longitudinal studies
  15. Males
  16. open access
  17. peer-reviewed
  18. Tobacco use
Badges
  1. open access
  2. peer-reviewed