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Organization and expression of canine olfactory receptor genes

By L. Issel-Tarver, J. Rine

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Abstract

Four members of the canine olfactory receptor gene family were characterized. The predicted proteins shared 40-64% identity with previously identified olfactory receptors. The four subfamilies identified in Southern hybridization experiments had as few as 2 and as many as 20 members. All four genes were expressed exclusively in olfactory epithelium. Expression of multiple members of the larger subfamilies was detected, suggesting that most if not all of the cross-hybridizing bands in genomic Southern blots represented actively transcribed olfactory receptor genes. Analysis of large DNA fragments using Southern blots of pulsed-field gels indicated that subfamily members were clustered together, and that two of the subfamilies were closely linked in the dog genome. Analysis of the four olfactory receptor gene subfamilies in 26 breeds of dog provided evidence that the number of genes per subfamily was stable in spite of differential selection on the basis of olfactory acuity in scent hounds, sight hounds, and toy breeds.

Date 1996
Publication Title Proceedings of the National Academy of Sciences of the United States of America
Volume 93
Issue 20
Pages 10897-10902
ISBN/ISSN 0027-8424
DOI 10.1073/pnas.93.20.10897
URL https://www.pnas.org/content/93/20/10897
Language English
Author Address Division of Genetics, Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA.
Additional Language English
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Tags
  1. Animal genetics
  2. Animals
  3. Biotechnology
  4. Canidae
  5. Canine
  6. Carnivores
  7. Dogs
  8. Evolution
  9. Gene expression
  10. Genes
  11. Genetics
  12. Mammals
  13. odors
  14. olfaction
  15. open access
  16. peer-reviewed
  17. Pets and companion animals
  18. receptors
Badges
  1. open access
  2. peer-reviewed