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Evaluation of a novel rodenticide: welfare assessment of fatal methaemoglobinaemia in adult rats ( Rattus norvegicus)

By T. J. Gibson, R. J. Quy, C. T. Eason, N. G. Gregory

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Abstract

This study assessed the welfare of rats ( Rattus norvegicus) poisoned with a lethal dose of the methaemoglobin (MetHb) inducing compound para-aminovalerophenone (PAVP). Twenty rats were orally gavaged with either PAVP (treated) or the vehicle only (control). Spontaneous and evoked behaviours were recorded and blood samples collected post mortem for analysis of MetHb%. Female and male rats received a mean (SEM) dose of 263 (3) and 199 (6) mg PAVP kg -1, respectively. Mean (SEM) time to death was 67 (16) and 354 (71) min for female and male rats, respectively. Control animals did not show any signs of intoxication. The time to death from methaemoglobinaemia in rats was significantly shorter than that reported for anticoagulants and there were no obvious signs of distress or pain.

Publication Title Animal Welfare
Volume 24
Issue 4
Pages 417-425
ISBN/ISSN 0962-7286
DOI 10.7120/09627286.24.4.417
Language English
Author Address Department of Production and Population Health, Royal Veterinary College, University of London, London, UK.tgibson@rvc.ac.uk
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Tags
  1. Analysis
  2. Animal models
  3. Animals
  4. Animal welfare
  5. Blood
  6. Brazil
  7. Death
  8. Developing countries
  9. Evaluation
  10. Hemoglobin
  11. Latin America
  12. Mammals
  13. models
  14. Pain
  15. peer-reviewed
  16. Pesticides and Drugs
  17. Poisoning
  18. postmortem examinations
  19. Rats
  20. rodenticides
  21. Rodents
  22. South America
  23. Threshold Countries
  24. toxicity
  25. United States of America
  26. vertebrates
Badges
  1. peer-reviewed