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Experimental control for the ovariectomized rat model: use of sham versus nonmanipulated animal

By M. C. Kruger, P. C. H. Morel

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Abstract

One of 2 models required by the U.S. Food and Drug Administration for registration of a treatment for osteoporosis, the ovariectomized (OVX) rat model, is widely used in scientific studies investigating sex hormone-deficient bone loss. The use of control nonhuman animals is critical because bone turnover may be affected by animal stress, use of anesthetic, and the mechanisms involved in wound healing. Historically, researchers have used sham-operated animals who undergo the same manipulations as the OVX rats, but ethical concerns require consideration of unmanipulated (unoperated) control animals to minimize animal distress and unnecessary procedures. Herein, we report the results of 3 studies including OVX, sham, and unmanipulated rats and the effects on bone mineral density and content (BMD/BMC) during 2 to 6 months postsurgery. Our data indicate that while OVX animals generally had lower BMD and BMC than animals in either of the control groups, no differences were observed between sham and unmanipulated animals at any of the time points assessed. However, because bone turnover is a long-term process, studies with longer duration and multiple endpoints are warranted to confirm these results.

Publication Title Journal of Applied Animal Welfare Science
Volume 19
Issue 1
Pages 73-80
ISBN/ISSN 1088-8705
DOI 10.1080/10888705.2015.1107727
Language English
Author Address Institute of Food, Nutrition and Human Health, Massey University, Palmerston North 4442, New Zealand.P.C.Morel@massey.ac.nz
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Tags
  1. Animal models
  2. Animals
  3. Animal welfare
  4. Bones
  5. Effect
  6. Employees
  7. Ethics
  8. Healing
  9. History
  10. Humans
  11. Mammals
  12. Men
  13. minerals
  14. models
  15. ovariectomy
  16. peer-reviewed
  17. Primates
  18. Rats
  19. registration
  20. Research
  21. researchers
  22. Rodents
  23. therapy
  24. vertebrates
  25. Wounds and injuries
Badges
  1. peer-reviewed