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To Group or Not to Group? Good Practice for Housing Male Laboratory Mice

By Sarah Kappel, Penny Hawkins, Michael T. Mendl

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It is widely recommended to group-house male laboratory mice because they are ‘social animals’, but male mice do not naturally share territories and aggression can be a serious welfare problem. Even without aggression, not all animals within a group will be in a state of positive welfare. Rather, many male mice may be negatively affected by the stress of repeated social defeat and subordination, raising concerns about welfare and also research validity. However, individual housing may not be an appropriate solution, given the welfare implications associated with no social contact. An essential question is whether it is in the best welfare interests of male mice to be group- or singly housed. This review explores the likely impacts—positive and negative—of both housing conditions, presents results of a survey of current practice and awareness of mouse behavior, and includes recommendations for good practice and future research. We conclude that whether group- or single-housing is better (or less worse) in any situation is highly context-dependent according to several factors including strain, age, social position, life experiences, and housing and husbandry protocols. It is important to recognise this and evaluate what is preferable from animal welfare and ethical perspectives in each case


Katie Osborn

Date 2017
Publication Title Animals
Volume 7
Issue 12
ISBN/ISSN 2076-2615
Publisher Multidisciplinary Digital Publishing Institute
Location of Publication Basel, Switzerland
DOI 10.3390/ani7120088
Language English
Additional Language English
Cite this work

Researchers should cite this work as follows:

  1. Animal health and hygiene
  2. Animal housing
  3. Animal welfare
  4. Mammals
  5. Mice
  6. refinement
  7. Rodents
  8. social order