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Assessment of Myocardial Perfusion at Rest and During Stress Using Dynamic First-Pass Contrast-Enhanced Magnetic Resonance Imaging in Healthy Dogs

By Henning Richter, Patrick R. Kircher, Fabiola B. Joerger, Erika Bruellmann, Matthias Dennler

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Abstract

Objective: To assess the feasibility of myocardial perfusion analysis in healthy dogs using dynamic contrast-enhanced cardiac magnetic resonance (DCE-MR) imaging at rest and during simulated stress with two doses of adenosine.

Animals: Ten healthy beagle dogs.

Procedures: Dogs were anesthetized and positioned in dorsal recumbency in a 3.0 Tesla MR scanner. Electrocardiogram-triggered dynamic T1-weighted ultrafast gradient echo images of three slices in short-axis orientation of the heart were acquired during breath holds and the first pass of gadolinium contrast. Image acquisition was performed after 4 min infusion of 140 μg/kg/min and 280 μg/kg/min adenosine and, after a washout period, without adenosine, respectively. Images were processed by dividing each slice into 6 radial segments and perfusion analysis was performed from signal intensity-time data.

Results: No differences in perfusion parameters were found between segments within any of the slices, but significant differences were found between slices for peak enhancement, accumulated enhancement, and the maximum upslope. In addition, significant differences were found within each slice between data at rest and during adenosine-induced stress for the relative and absolute maximum upslope, relative peak enhancement, time to peak, and accumulated enhancement although inter-individual variation was large and no difference was found between the two stress tests for some parameters.

Conclusion and Clinical Relevance: Results of this study showed that rest and stress myocardial perfusion can be assessed using DCE-CMR in dogs using the methods described. Both, adenosine dose and slice appear to affect perfusion parameters in healthy dogs and individual response to adenosine was variable.

Submitter

Marcy Wilhelm-South

Purdue University

Publication Title Frontiers in Veterinary Science
Volume 5
Pages 9
DOI 10.3389/fvets.2018.00211
URL https://www.frontiersin.org/articles/10.3389/fvets.2018.00211/full
Cite this work

Researchers should cite this work as follows:

  • Henning Richter; Patrick R. Kircher; Fabiola B. Joerger; Erika Bruellmann; Matthias Dennler (2018), "Assessment of Myocardial Perfusion at Rest and During Stress Using Dynamic First-Pass Contrast-Enhanced Magnetic Resonance Imaging in Healthy Dogs," https://habricentral.org/resources/63911.

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Tags
  1. Adenosine
  2. Animal roles
  3. Dogs
  4. Heart
  5. Magnetic resonance imaging
  6. Mammals
  7. open access
  8. Pets and companion animals
Badges
  1. open access