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Hendra Virus Vaccine, a One Health Approach to Protecting Horse, Human, and Environmental Health

By Deborah Middleton, Jackie Pallister, Reuben Klein, Yan-Ru Feng, Jessica Haining, Rachel Arkinstall, Leah Frazer, Jin-An Huang, Nigel Edwards, Mark Wareing, Martin Elhay, Zia Hashmi, John Bingham, Manabu Yamada, Dayna Johnson, John White, Adam Foord, Hans G. Heine, Glenn A. Marsh, Christopher C. Broder, Lin-Fa Wang

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In recent years, the emergence of several highly pathogenic  zoonotic  diseases in humans has led to a renewed emphasis on the interconnectedness of human, animal, and environmental health, otherwise known as One Health. For example, Hendra virus (HeV), a zoonotic paramyxovirus, was discovered in 1994, and since then, infections have occurred  in 7 humans, each of whom had a strong epidemiologic link to similarly affected horses. As a consequence of these outbreaks, eradication of bat populations was dis-cussed, despite their crucial environmental roles in pollination and reduction of the insect population. We describe the development and evaluation of a vaccine for horses with the potential for breaking the chain of HeV transmission from bats to horses to humans, thereby protecting horse, human, and environmental health. The HeV vaccine for horses is a  key example of a One Health approach to   the control of human disease.


Marcy Wilhelm-South

Purdue University

Date 2014
Publication Title Emerging Infectious Diseases
Volume 20
Issue 3
Pages 372-379
Language English
Additional Language English
Cite this work

Researchers should cite this work as follows:

  1. Animal health and hygiene
  2. Animal welfare
  3. Australia
  4. Bats
  5. Environment
  6. Health
  7. Horses
  8. One Health
  9. open access
  10. vaccination
  11. Virus diseases
  12. Zoonoses
  1. open access