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Fatal Tuberculosis in a Free-Ranging African Elephant and One Health Implications of Human Pathogens in Wildlife

By Michele A. Miller, Peter Buss, Eduard O. Roos, Guy Hausler, Anzaan Dippenaar, Emily Mitchell, Louis van Schalkwyk, Suelee Robbe-Austerman, W. Ray Waters, Alina Sikar-Gang, Konstantin P. Lyashchenko, Sven D. C. Parsons, Robin Warren, Paul van Helden

Category Journal Articles
Abstract

Tuberculosis (TB) in humans is a global public health concern and the discovery of animal cases of Mycobacterium tuberculosis (Mtb) infection and disease, especially in multi-host settings, also has significant implications for public health, veterinary disease control, and conservation endeavors. This paper describes a fatal case of Mtb disease in a free-ranging African elephant (Loxodonta africana) in a high human TB burden region. Necropsy revealed extensive granulomatous pneumonia, from which Mtb was isolated and identified as a member of LAM3/F11 lineage; a common lineage found in humans in South Africa. These findings are contextualized within a framework of emerging Mtb disease in wildlife globally and highlights the importance of the One Health paradigm in addressing this anthroponotic threat to wildlife and the zoonotic implications.

Submitter

Marcy Wilhelm-South

Purdue University

Date 2019
Publication Title Frontiers in Veterinary Science
Volume 6
Pages 8
DOI 10.3389/fvets.2019.00018
URL https://www.frontiersin.org/articles/10.3389/fvets.2019.00018/full
Language English
Additional Language English
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Tags
  1. Animal health and hygiene
  2. Animal roles
  3. Animal welfare
  4. Elephants
  5. Health
  6. One Health
  7. open access
  8. peer-reviewed
  9. Tuberculosis
  10. Wild animals
  11. Zoonoses
Badges
  1. open access
  2. peer-reviewed