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Protein expression and genetic variability of canine Can f 1 in golden and Labrador retriever service dogs

By C. Breitenbuecher, J. M. Belanger, K. Levy, P. Mundell, V. Fates, L. Gershony, T. R. Famula, A. M. Oberbauer

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Background: Valued for trainability in diverse tasks, dogs are the primary service animal used to assist individuals with disabilities. Despite their utility, many people in need of service dogs are sensitive to the primary dog allergen, Can f 1, encoded by the Lipocalin 1 gene (LCN1). Several organizations specifically breed service dogs to meet special needs and would like to reduce allergenic potential if possible. In this study, we evaluated the expression of Can f 1 protein and the inherent variability of LCN1 in two breeds used extensively as service dogs. Saliva samples from equal numbers of male and female Labrador retrievers (n=12), golden retrievers (n=12), and Labradorgolden crosses (n=12) were collected 1 h after the morning meal. Can f 1 protein concentrations in the saliva were measured by ELISA, and the LCN1 5′ and 3′ UTRs and exons sequenced. Results: There was no sex effect (p>0.2) nor time-of-day effect; however, Can f 1 protein levels varied by breed with Labrador retrievers being lower than golden retrievers (3.180.51 and 5.350.52 g/ml, respectively, p

Date 2016
Publication Title Canine Genetics and Epidemiology
Volume 3
Issue 3
Pages 8
ISBN/ISSN 2052-6687
Publisher Springer
DOI doi.org/10.1186/s40575-016-0031-3
URL https://cgejournal.biomedcentral.com/articles/10.1186/s40575-016-0031-3
Language English
Author Address Department of Animal Science, University of California, One Shields Ave, Davis, CA 95616, USA.amoberbauer@ucdavis.edu
Additional Language English
Cite this work

Researchers should cite this work as follows:

  1. Allergy
  2. Animal genetics
  3. Animals
  4. APEC countries
  5. Breed differences
  6. Breeding
  7. California
  8. Canidae
  9. Canine
  10. Carnivores
  11. Crossbreds
  12. Developed countries
  13. DNA
  14. Dog Breeds
  15. Dogs
  16. Ecology
  17. expression
  18. Genes
  19. Genetic factors
  20. Genetics
  21. Genetic variation
  22. Genotypes
  23. Heredity
  24. Humans
  25. Immunology
  26. Injuries
  27. Mammals
  28. Men
  29. Non-communicable diseases and injuries
  30. North America
  31. OECD countries
  32. open access
  33. pathology
  34. Pets and companion animals
  35. physiology
  36. polymorphism
  37. predisposition
  38. Primates
  39. Resistance and Immunity
  40. risk factors
  41. saliva
  42. sex differences
  43. susceptibility
  44. temporal variation
  45. United States of America
  46. values
  47. vertebrates
  48. Working animals
  49. Zoology
  1. open access