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Clinical pathology and cardiovascular parameters are not influenced by housing rats under increased environmental complexity

By L. F. Mikkelsen, D. B. Sorensen, T. Krohn, B. Lauritzen, N. Dragsted, A. K. Hansen, J. L. Ottesen

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Abstract

Since the release of the revised Appendix A from the Council of Europe for housing of laboratory animals there have been claims that laboratory animals should be housed under more complex conditions; known popularly as enrichment. A number of studies have expressed concerns that this may increase uncontrollable variation in the animals, thereby creating the need for greater numbers of animals. Within neurobiology there would appear to be a scientific basis for such concern. However, even though this may be used as an argument for denying the animal environmental enrichment, it is unclear whether there is any basis for concern within other research areas. The aim of this study, therefore, was to explore whether clinical pathology and cardiovascular parameters were influenced by housing rats under environmentally enriched conditions. Male, Sprague-Dawley rats were housed under three different regimes: non-enriched, standard-enriched (according to the guidelines of the Council of Europe) and extra-enriched with a shelf and higher cages. All housing forms were based upon commercially available, standardised equipment. A total of 41 different parameters were monitored via clinical pathology, telemetry and coagulation tests and virtually no differences were observed in relation to the manner in which the rats were housed. The uncontrollable variation observed in our study was compared to within-strain variation data supplied from the breeder and was relatively low in all three types of housing. We conclude, based upon our studies in male, Sprague-Dawley rats, that so far there is no basis for concern that enriched housing will lead to increased group sizes when using animals for research within this field and, as such, there is no reason not to enrich the environment of such rats.

Date 2010
Publication Title Animal Welfare
Volume 19
Issue 4
Pages 449-460
ISBN/ISSN 0962-7286
Language English
Author Address Novo Nordisk A/S, Novo Nordisk Park, DK-2760 Malov, Denmark. lfmi@novonordisk.com
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Tags
  1. Animal genetics
  2. Animal housing
  3. Animal models
  4. Animal physiology
  5. Animal rights
  6. Animal science
  7. Animal welfare
  8. Biological resources
  9. Breeding
  10. Cages
  11. Cardiovascular health
  12. Circulatory system
  13. Clinical aspects
  14. Enrichment
  15. Europe
  16. Guidelines
  17. Laboratory and experimental animals
  18. Laboratory animal science
  19. Mammals
  20. models
  21. Parasites
  22. pathology
  23. peer-reviewed
  24. radiotelemetry
  25. Rats
  26. recommendations
  27. Research
  28. Rodents
  29. Studies
  30. telemetry
  31. variation
Badges
  1. peer-reviewed