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Effects of a Nutritional Supplement on Cognitive Function in Aged Dogs and on Synaptic Function of Primary Cultured Neurons

By Maria Elena Pero, Laura Cortese, Vincenzo Mastellone, Raffaella Tudisco, Nadia Musco, Anna Scandurra, Biagio D’Aniello, Giuseppe Vassalotti, Francesca Bartolini, Pietro Lombardi

Category Journal Articles
Abstract

The objective of this research was to investigate the efficacy of DìSeniorTM, a nutraceutical formulated to improve cognitive functions in elderly dogs. To this purpose, some clinical and metabolic investigations and a spatial navigation test were performed in treated and untreated dogs. Moreover, the nutraceutical was also tested on primary hippocampal neuron cultures. Results showed no adverse effects on the dogs’ health and a positive effect on learning. In vitro effects on neuron cultures showed an increase in the level of cFOS in treated neurons compared with the vehicle, suggesting that DiSeniorTM has also a positive effect on neuronal functions. Overall, this study suggests that DiSeniorTM can exert a beneficial effect on aged dogs by preventing the negative effects of aging on cognition. Further studies are needed to assess the mechanisms by which it acts on neurons and the specific effect of the different components alone or combined. 

Submitter

Marcy Wilhelm-South

Purdue University

Date 2019
Publication Title Animals
Volume 9
Issue 7
Pages 13
Publisher MDPI
DOI 10.3390/ani9070393
URL https://www.mdpi.com/2076-2615/9/7/393
Language English
Additional Language English
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Tags
  1. Aging
  2. Animal roles
  3. Cognitive disorders
  4. Dogs
  5. Mammals
  6. open access
  7. Pets and companion animals
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  1. open access