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Tumor Infiltrating Lymphocytes in Pet Rabbit Mammary Carcinomas: A Study with Relevance to Comparative Pathology

By Sandra Schöniger, Sophie Degner, Qian Zhang, Claudia Schandelmaier, Heike Aupperle-Lellbach, Bharat Jasani, Heinz-Adolf Schoon

Category Journal Articles
Abstract

Tumor infiltrating lymphocytes (TILs) serve as prognostic biomarker in human breast cancer. Rabbits have the potential to act as animal model for human breast cancer, and close similarities exist between the rabbit and human immune system. The aim of this study is to characterize TILs in pet rabbit mammary carcinomas and to statistically correlate results with histological and immunohistochemical tumor characteristics. Microscopic evaluation of TILs was performed in hematoxylin and eosin stained sections of 107 rabbit mammary carcinomas according to international guidelines for human breast cancer. Data on histological features of malignancy, estrogen and progesterone receptor status and calponin expression were obtained from the data base. This study revealed a statistical association between stromal TILs in the central tumor (CT) and infiltrative margin. Higher maximal percentages of stromal TILs at the CT were statistically correlated with decreased mitotic count and lower tumor grade. An increased number of calponin positive tumor cells was statistically associated with a lower mitotic count and a higher percentage of stromal TILs. Results suggest that higher percentages of stromal TILs are useful biomarkers that may point toward a favorable prognosis in rabbit mammary carcinomas and support the concept of the use of rabbits for translational research.

Submitter

Marcy Wilhelm-South

Purdue University

Date 2020
Publication Title Animals
Volume 10
Issue 8
Pages 17
Publisher MDPI
DOI 10.3390/ani10081437
URL https://www.mdpi.com/2076-2615/10/8/1437
Language English
Additional Language English
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Tags
  1. Animal roles
  2. Cancer
  3. open access
  4. Pets and companion animals
  5. rabbits
  6. Veterinary medicine
Badges
  1. open access