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Analysis of Genetic Diversity in the Czech Spotted Dog

By Karolína Machová, Anita Kranjˇceviˇcová, Luboš Vostrý, Emil Krupa

Category Journal Articles
Abstract

Loss off genetic diversity negatively affects most of the modern dog breeds. However, no breed created strictly for laboratory purposes has been analyzed so far. In this paper, we sought to explore by pedigree analysis exactly such a breed—the Czech Spotted Dog (CSD). The pedigree contained a total of 2010 individuals registered since the second half of the 20th century. Parameters such as the mean average relatedness, coefficient of inbreeding, effective population size, effective number of founders, ancestors and founder genomes and loss of genetic diversity—which was calculated based on the reference population and pedigree completeness—were used to assess genetic variability. Compared to the founding population, the reference population lost 38.2% of its genetic diversity, of which 26% is due to random genetic drift and 12.2% is due to the uneven contribution of the founders. The reference population is highly inbred and related. The average inbreeding coefficient is 36.45%, and the mean average relatedness is 74.83%. The effective population size calculated based on the increase of inbreeding coefficient is 10.28. Thus, the Czech Spotted Dog suffered significant losses of genetic diversity that threaten its future existence. 

Submitter

Marcy Wilhelm-South

Purdue University

Date 2020
Publication Title Animals
Volume 10
Issue 8
Pages 11
Publisher MDPI
DOI 10.3390/ani10081416
URL https://www.mdpi.com/2076-2615/10/8/1416
Language English
Additional Language English
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Tags
  1. Animal roles
  2. Genetic diversity
  3. Genetics
  4. Inbreeding
  5. open access
  6. Pets and companion animals
Badges
  1. open access