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A Review of the Impact of Neuter Status on Expression of Inherited Conditions in Dogs

By Anita M. Oberbauer, Janelle M. Belanger, Thomas R. Famula

Category Journal Articles

Gonadectomy is an important reproductive management tool employed in many countries, and is highly prevalent in the US with an estimated 85% of dogs being neutered. Despite the societal benefits in pet population control, negative associations between neuter status, and health conditions have been reported in recent years. Most particularly observed are the consequences of early age neutering. Knowing that different physiological systems rely upon gonadal steroids during development and physiological maintenance, studies have been undertaken to assess the impact of neuter status on multiple body and organ systems. For some inherited conditions, neutering is associated with an increased risk of expression. Neutering has also been associated with altered metabolism and a predisposition for weight gain in dogs, which may confound the detected risk association between neutering and disease expression. This review summarizes the effects of neutering on cancer, orthopedic, and immune disorders in the dog and also explores the potentially exacerbating factor of body weight.


Marcy Wilhelm-South

Purdue University

Date 2019
Publication Title Frontiers in Veterinary Science
Volume 6
Pages 11
DOI 10.3389/fvets.2019.00397
Language English
Additional Language English
Cite this work

Researchers should cite this work as follows:

  1. Animal diseases
  2. Animal roles
  3. Dogs
  4. Mammals
  5. open access
  6. Pets and companion animals
  7. Spaying and neutering
  1. open access