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  1. Adenoviral Gene Transfer of Gremlin Modulates Vascular Endothelial Growth Factor-A-Induced Angiogenesis in Porcine Myocardium

    Contributor(s):: Pajula, J. J., Halonen, P. J., Hätinen, O. P., Ylä-Herttuala, S., Nurro, J.

  2. Effects of in ovo injection of serotonin on behavior and hypothalamic genes expression in post hatch-chicks

    Contributor(s):: Chenxuan, Huang, Qiaoxian, Yue, Yifan, Chen, Dehe, Wang, Rongyan, Zhou, Guoxian, Zhao, Hui, Chen

  3. Continuous and Real-Time In Vivo Autobioluminescent Imaging in a Mouse Model

    Contributor(s):: Yip, D., Kirkpatrick, A., Xu, T., Masi, T., Stephenson, S., Ripp, S., Close, D.

  4. CRISPR/Cas9 Technology in Translational Biomedicine

    Contributor(s):: Leonova, E. I., Gainetdinov, R. R.

  5. Pharmacological inhibition of histone deacetylase reduces NADPH oxidase expression, oxidative stress and the progression of atherosclerotic lesions in hypercholesterolemic apolipoprotein E-deficient mice; potential implications for human atherosclero

    Contributor(s):: Manea, S. A., Vlad, M. L., Fenyo, I. M., Lazar, A. G., Raicu, M., Muresian, H., Simionescu, M., Manea, A.

  6. Blockade of histone deacetylation in the brain modulates the expression of transcription factors c-FOS and ZENK and potentiates the formation of long-term memory in neonatal chicks

    Contributor(s):: Toporova, K. A., Anokhin, K. V., Tiunova, A. A.

  7. Canine olfactory genetics

    Contributor(s):: Quignon, P., Robin, S., Galibert, F.

  8. Organization and expression of canine olfactory receptor genes

    Full-text: Available

    | Contributor(s):: Issel-Tarver, L., Rine, J.

    Four members of the canine olfactory receptor gene family were characterized. The predicted proteins shared 40-64% identity with previously identified olfactory receptors. The four subfamilies identified in Southern hybridization experiments had as few as 2 and as many as 20 members. All four...

  9. Genetic and dietary effects on chicken heterophil function and immune response to Salmonella enteritidis

    | Contributor(s):: Sarah Beth Redmond, Susan J. Lamont (adviser)

    The function of the chicken innate immune system against pathogens is affected by genetic background and immune modulating diet. Heterophils from broiler, Leghorn, and Fayoumi birds showed differential expression of immune genes when stimulated with Salmonella enteritidis (SE) bacteria, a...

  10. The effects of low protein during gestation on mouse pancreas development and beta cell regeneration

    | Contributor(s):: Aaron Richard Cox, David Hill (adviser)

    Effects of a low protein (LP) diet during gestation on the metabolism of rat offspring have been well characterized and leads to glucose intolerance in adulthood. It is unknown how LP impacts endocrine pancreas development in the mouse, or whether this affects future β-cell plasticity....

  11. Osteoclast ontogeny-experimental studies in two osteopetrotic mutations in the rat: A Dissertation

    | Contributor(s):: Matthew Joseph Cielinski

    Osteopetrosis is a metabolic bone disease in mammals characterized by a generalized skeletal sclerosis caused by reduced bone resorption. This reduced bone resorption is manifested in afflicted animals by abnormal bone shape, reduced or absent marrow cavities, extramedullary hemopoiesis, abnormal...

  12. Whole transcriptome response of chicken spleen and peripheral blood leukocytes to avian pathogenic Escherichia coli

    | Contributor(s):: Erin Elizabeth Sandford, Susan J. Lamont (adviser)

    A greater understanding of the immune response after infection can form the necessary foundation of knowledge needed to enhance immunity through genetic selection. Whole genome microarrays allow for comprehensive analysis of the transcriptome. The transcriptomic responses of spleen and peripheral...

  13. Gene-environment interaction in the onset of eczema in infancy: filaggrin loss-of-function mutations enhanced by neonatal cat exposure

    | Contributor(s):: Bisgaard, H., Simpson, A., Palmer, C. N., Bonnelykke, K., McLean, I., Mukhopadhyay, S., Pipper, C. B., Halkjaer, L. B., Lipworth, B., Hankinson, J., Woodcock, A., Custovic, A.

    BackgroundLoss-of-function variants in the gene encoding filaggrin (FLG) are major determinants of eczema. We hypothesized that weakening of the physical barrier in FLG-deficient individuals may potentiate the effect of environmental exposures. Therefore, we investigated whether there is an...

  14. The social environment and the epigenome

    | Contributor(s):: Szyf, Moshe, McGowan, Patrick O., Turecki, Gustavo, Meaney, Michael J.

  15. Domestication - from behaviour to genes and back again

    | Contributor(s):: Jensen, P.

    During domestication, animals have adapted with respect to behaviour and an array of other traits. This tends to give rise to a specific domestication phenotype, involving similar changes in colour, size, physiology and behaviour among different species. Hence, domestication offers a model for...

  16. Animal models of eating disorder traits

    | Contributor(s):: Kas, Martien J. H., Adan, Roger A. H.

  17. Differences in the expression of genes in lame and normal broiler chickens identified by subtraction hybridisation

    | Contributor(s):: Butterworth, A., Reeves, N. A., Knowles, T. G., Kestin, S. C.

    In the UK, broiler chickens are normally slaughtered at about six weeks of age when they weigh approximately 2.2 kg; this contrasts with the growth of an 'unimproved' traditional strain of bird such as a White Sussex, which would weigh about 800 g at the same age. Lameness, characterised by...

  18. Domestication, selection, behaviour and welfare of animals - genetic mechanisms for rapid responses

    | Contributor(s):: Jensen, P.

    Increased production has been the major goal of animal breeding for many decades, and the correlated side-effects have grown to become a major issue in animal welfare. In this paper, the main genetic mechanisms in which such side-effects may occur are reviewed with examples from our own research...