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  1. Genetic analysis of reactivity to humans in Goettingen minipigs

    Contributor(s):: Kohn, F., Sharifi, A. R., Simianer, H.

    Goettingen minipigs are laboratory animals with an increasing demand over the last few years. At the moment, Goettingen minipigs are not selected for a low reactivity to humans and this trait is not included in the breeding programme. However, it is obvious that there is a need for genetically...

  2. Genetic engineering and other factors that might affect human-animal interactions in the research setting

    Contributor(s):: Comber, J., Griffin, G.

    Evidence exists, particularly in the welfare literature of nonhuman animals on the farm, that the interaction between nonhuman animals and the personnel who care for them can have a strong effect on the animals' behavior, productivity, and welfare. Among species commonly used for biomedical...

  3. Genetically modified animals in research: an analysis of applications submitted to ethics committees on animal experimentation in Sweden

    Contributor(s):: Nordgren, A., Rocklinsberg, H.

    The use of genetically modified (GM) animals in biomedical research has increased during recent years and its ethical aspects have been subject to ongoing academic discussion. In order to reinforce this discussion, we analysed applications submitted to animal ethics committees in Sweden during...

  4. Genetically modified laboratory animals - what welfare problems do they face?

    Contributor(s):: Buehr, M., Hjorth, P. J., Hansen, A. K., Sandoe, P.

    In this article, we respond to public concern expressed about the welfare of genetically modified (GM) non-human animals. As a contribution to the debate on this subject, we attempt in this article to determine in what situations the practice of genetic modification in rodents may generate...

  5. Gerbils prefer partially darkened cages

    Contributor(s):: Broek, F. A. R. van den, Klompmaker, H., Bakker, R., Beynen, A. C.

  6. Global harmonization of pain and distress classification systems: current analysis and opportunity for change

    Contributor(s):: Purves, K. E.

    When humans suffer pain or distress, they are generally able to describe their experience to others, including doctors. Medical professionals are also able to convey the likelihood of pain and distress to humans who are voluntarily participating in clinical research trials. The same is not true...

  7. Group housing and enrichment cages for breeding, fattening and laboratory rabbits

    Contributor(s):: Stauffacher, M.

  8. Guidelines development and scientific uncertainty: use of previous case studies to promote efficient production of guidelines on the care and use of fish in research, teaching and testing

    Contributor(s):: Griffin, G., Gauthier, C.

    The Canadian Council on Animal Care (CCAC) develops guidelines on issues of current and emerging concern in response to the needs of the scientific community, advances in animal care, and the needs of the CCAC Assessment Programme. Guidelines are developed by subcommittees of experts, and are...

  9. Guidelines for the ethical use of animals in applied ethology studies. (International Society for Applied Ethology Special Issue)

    Contributor(s):: Sherwin, C. M., Christiansen, S. B., Duncan, I. J., Erhard, H. W., Lay, D. C., Jr., Mench, J. A., O'Connor, C. E., Petherick, J. C.

    Applied ethology has a continuing interest in the promotion of animal welfare and the ethical treatment of animals used in research. However, in contrast to some other fields involving animal research, there are currently no guidelines written specifically for those engaged in applied ethology...

  10. Habituation and extinction in an approach-avoidance test: an example with sheep

    Contributor(s):: Erhard, H. W., Elston, D. A., Davidson, G. C.

    During a behavioural test, the test animal's perception of the test situation may change, e.g. as a result of habituation. This change can occur within a test or between repetitions of a test. It is particularly important in the arena test because in an approach-avoidance situation, the negative...

  11. Harmonising the definition of refinement

    Contributor(s):: Buchanan-Smith, H. M., Rennie, A. E., Vitale, A., Pollo, S., Prescott, M. J., Morton, D. B.

    Russell and Burch's Three Rs (replacement, reduction and refinement) remain the cornerstone for principles guiding humane experimental research. However, the concept of refinement has evolved considerably since its first inception and there have been numerous interpretations, some of which are...

  12. Health Technology Assessment as a template for assessments in laboratory animal science with a focus on phenotyping protocols

    Contributor(s):: Thon, R., Ritskes-Hoitinga, M., Vondeling, H.

    This study introduces Health Technology Assessment (HTA) - a systematic, evidence-based, multidisciplinary approach to assessing human health technologies, aimed at supporting decision-making in health policy and clinical practice - into laboratory animal science. A conceptual presentation is...

  13. Hormonal stress response of laboratory mice to conventional and minimally invasive bleeding techniques

    Contributor(s):: Voigt, C. C., Klockner, P., Touma, C., Neuschl, C., Brockmann, G., Goritz, F., Palme, R., Thomsen, R.

  14. Housing and welfare in laboratory rats: the welfare implications of social isolation and social contact among females

    Contributor(s):: Hurst, J. L., Barnard, C. J., Nevison, C. M., West, C. D.

  15. Housing and welfare in laboratory rats: welfare implications of isolation and social contact among caged males

    Contributor(s):: Hurst, J. L., Barnard, C. J., Nevison, C. M., West, C. D.

  16. Housing conditions affect self-administration of anxiolytic by laboratory mice

    Contributor(s):: Sherwin, C. M., Olsson, I. A. S.

    Tests of emotionality conducted outside the home-cage show that rodents from standard laboratory housing are more anxious than animals from enriched housing; however, it is not known if this also indicates increased anxiety within the home-cage. We used a novel method, recording the...

  17. How do human-animal emotional relationships influence public perceptions of animal use?

    Contributor(s):: Cox, L., Montrose, T.

    Human-animal emotional relationships have a complicated interplay with public perceptions of the morality of animal use. Humans may build emotional relationships with companion species. These species are not usually intensively farmed in the United Kingdom, but they may be utilized during animal...

  18. Human-animal interactions - an outline of studies conducted at the IGHZ [Institute of Genetics and Animal Breeding, Polish Academy of Sciences]

    Contributor(s):: Jezierski, T.

  19. Human-animal interactions and animal welfare in conventionally and pen-housed rats

    Contributor(s):: Augustsson, H., Lindberg, L., Hoglund, A. U., Dahlborn, K.

    The main aim of the present study was to explore the significance of large group/greater pen housing (PH) versus standard Makrolon caging (ST) in three behaviour tests related to human-animal interactions in the adult male laboratory rat. The rats' perception of human interaction was tested in...

  20. Human-animal relationship in the research lab: a discussion by the Refinement and Enrichment Forum

    Contributor(s):: Abney, D., Conlee, K., Cunneen, M., Down, N., Lang, T., Patterson-Kane, E., Skoumbourdis, E., Reinhardt, V.