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  1. Titrating the preferences of altered lighting against temperature in female CD-1 laboratory mice, Mus musculus

    Contributor(s):: Davis, Haley J., Barabas, Amanda J., Gaskill, Brianna N.

  2. An examination of nest-building behaviour using five different nesting materials in C57BL/6J and BALB/c mice

    Contributor(s):: Obermueller, B., Castellani, C., Till, H., Reininger-Gutmann, B., Singer, G.

  3. Enriched laboratory housing increases sensitivity to social stress in female California mice (Peromyscus californicus)

    Contributor(s):: Minie, Vanessa A., Petric, Radmila, Ramos-Maciel, Stephanie, Wright, Emily C., Trainor, Brian C., Duque-Wilckens, Natalia

  4. Four- and six-hour urinary albumin excretion is a valuable alternative to 24-h urinary albumin excretion in male db/db mice

    Contributor(s):: Norgaard, S. A., Sand, F. W., Sorensen, D. B., Sondergaard, H.

  5. Hang on: an evaluation of the hemp rope as environmental enrichment in C57BL/6 mice

    Contributor(s):: Gjendal, K., Sorensen, D. B., Kiersgaard, M. K., Ottesen, J. L.

  6. Continuous and Real-Time In Vivo Autobioluminescent Imaging in a Mouse Model

    Contributor(s):: Yip, D., Kirkpatrick, A., Xu, T., Masi, T., Stephenson, S., Ripp, S., Close, D.

  7. Pharmacological inhibition of histone deacetylase reduces NADPH oxidase expression, oxidative stress and the progression of atherosclerotic lesions in hypercholesterolemic apolipoprotein E-deficient mice; potential implications for human atherosclero

    Contributor(s):: Manea, S. A., Vlad, M. L., Fenyo, I. M., Lazar, A. G., Raicu, M., Muresian, H., Simionescu, M., Manea, A.

  8. The ‘Cage Climber’ - A new enrichment for use in large-dimensioned mouse facilities

    Contributor(s):: Vogt, Miriam Annika, Mertens, Sinja, Serba, Susanne, Palme, Rupert, Chourbaji, Sabine

    Environmental Enrichment has been shown in experimental contexts to have clear and often beneficial effects on animal physiology and behavior. Housing prior to experiments can represent a large proportion of an animal’s living conditions, and improving housing conditions can be seen as...

  9. Transgressive Little Pests: Hiker Descriptions of “Shelter Mice” on the Appalachian Trail

    Contributor(s):: Marx, Kate

    Running between Springer Mountain in the state of Georgia, and Mount Katahdin in Maine, the Appalachian Trail (AT) is a more than 2,000 mile long “wilderness” corridor in the United States. People aiming to undertake a trek of the entire length of the trail can expect to spend approximately six...

  10. Use of spontaneous behaviour measures to assess pain in laboratory rats and mice: How are we progressing?

    Contributor(s):: Whittaker, Alexandra L., Howarth, Gordon S.

    The understanding and recognition of pain in laboratory rats and mice has advanced considerably in recent times. However, there is evidence that despite these advances, analgesics are still relatively underutilised in these species. One possible contributing influence to this is the difficulty in...

  11. Responses by wild house mice (Mus musculus) to various stimuli in a novel environment

    Full-text: Available

    | Contributor(s):: Witmer, Gary W., Snow, Nathan P., Moulton, Rachael S.

    House mice (Mus musculus) pose a threat to the native flora and fauna on islands, and can cause significant damage wherever they have been introduced. Methods used to eradicate invasive rodents, like house mice, at high population densities may not be appropriate for intercepting them at lower...

  12. The naked truth: Breeding performance in nude mice with and without nesting material

    | Contributor(s):: Gaskill, Brianna N., Winnicker, Christina, Garner, Joseph P., Pritchett-Corning, Kathleen R.

    In laboratories, mice are housed at ambient temperatures between 20 and 24°C, which is below their lower critical temperature of 30°C, but comfortable for human workers. Thus, mice are under chronic thermal stress, which can compromise many aspects of physiology from metabolism to pup growth....

  13. Impact of inhalation anaesthesia, surgery and analgesic treatment on home cage behaviour in laboratory mice

    | Contributor(s):: Cesarovic, Nikola, Arras, Margarete, Jirkof, Paulin

    Anaesthesia and analgesia are used frequently in laboratory routine to ensure animal welfare and good scientific outcomes in experiments that may elicit pain or require immobilisation of the animal. However, there is concern regarding the effect of these procedures on animal behaviour in...

  14. Housing of female mice in a new environment and its influence on post-surgical behaviour and recovery

    Full-text: Available

    | Contributor(s):: Jirkof, Paulin, Cesarovic, Nikola, Rettich, Andreas, Arras, Margarete

    The transportation of mice into a new clean cage after surgery is a standard procedure but might have detrimental effects during the critical post-surgical recovery phase. To analyse the effect of post-surgical housing, female C57BL/6J mice housed in their familiar home cage or in a new...

  15. Critical care and survival of fragile animals: The case of Prrxl1 knockout mice

    | Contributor(s):: Monteiro, Clara, Dourado, Margarida, Matos, Mariana, Duarte, Isabel, Lamas, Sofia, Galhardo, Vasco, Lima, Deolinda

    The generation of genetically modified animal models in which a given gene is permanently deleted or overexpressed, sometimes results in fragile phenotypes characterized by high morbidity and premature death. This undesired outcome creates important welfare difficulties and poses a huge...

  16. Variation in stress reactivity affects cage-induced stereotypies in female CD-1 (ICR) mice

    | Contributor(s):: Engel, Anna Katarina J., Gross, Alexandra N., Richter, S. Helene, Rommen, Jonas, Touma, Chadi, Würbel, Hanno

    Stereotypies in captive animals typically occur under conditions that are stressful for the animals, and there is some anecdotal evidence that stress levels during early stereotypy development predict later stereotypy levels. Based on this and on the involvement of stress in the behavioural...

  17. Simply a nest? Effects of different enrichments on stereotypic and anxiety-related behaviour in mice

    | Contributor(s):: Gross, Alexandra Nam-Mi, Engel, Anna Katarina Julia, Würbel, Hanno

    Improving the home cages of laboratory mice by environmental enrichment has been widely used to reduce cage stereotypies and anxiety-related behaviour in behavioural tests. However, enrichment studies differ substantially in type, complexity and variation of enrichments. Therefore, it is unclear...

  18. A comparison of a manual and an automated behavioural analysis method for assessing post-operative pain in mice

    | Contributor(s):: Miller, Amy L., Flecknell, Paul A., Leach, Matthew C., Roughan, John V.

    Current methods of identifying and analysing behavioural signs of pain in mice are highly time consuming and labour intensive. HomeCageScan (HCS) is an automated analysis system that may offer an alternative to manual scoring. Thirty-two male mice undergoing vasectomy were filmed before and at 1h...

  19. Clustered environmental enrichments induce more aggression and stereotypic behaviour than do dispersed enrichments in female mice

    | Contributor(s):: Akre, Anne Kathrine, Bakken, Morten, Hovland, Anne Lene, Palme, Rupert, Mason, Georgia

    Adding environmental enrichments to a previously resource-poor cage or enclosure can sometimes cause elevated aggression in socially housed animals, due to competition over the provided resources. Here, using female C57BL/6J mice, we investigated whether the way that environmental enrichments are...

  20. The inescapable problem of lab animal restraint | Garet Lahvis | TEDxMtHood

    Full-text: Available

    | Contributor(s):: Garet Lahvis

      Garet Lahvis is a pioneer in academic research on the mental experiences of laboratory mice and is an internationally recognized scientific expert on empathy. Using sophisticated behavioral experiments, his laboratory discovered that mice enjoy living with other mice and they can also...