You are here: Home / Tags / Mice / All Categories

Tags: Mice

All Categories (1-20 of 161)

  1. Transgressive Little Pests: Hiker Descriptions of “Shelter Mice” on the Appalachian Trail

    Contributor(s):: Marx, Kate

    Running between Springer Mountain in the state of Georgia, and Mount Katahdin in Maine, the Appalachian Trail (AT) is a more than 2,000 mile long “wilderness” corridor in the United States. People aiming to undertake a trek of the entire length of the trail can expect to spend approximately six...

  2. Use of spontaneous behaviour measures to assess pain in laboratory rats and mice: How are we progressing?

    Contributor(s):: Whittaker, Alexandra L., Howarth, Gordon S.

    The understanding and recognition of pain in laboratory rats and mice has advanced considerably in recent times. However, there is evidence that despite these advances, analgesics are still relatively underutilised in these species. One possible contributing influence to this is the difficulty in...

  3. The naked truth: Breeding performance in nude mice with and without nesting material

    Contributor(s):: Gaskill, Brianna N., Winnicker, Christina, Garner, Joseph P., Pritchett-Corning, Kathleen R.

    In laboratories, mice are housed at ambient temperatures between 20 and 24°C, which is below their lower critical temperature of 30°C, but comfortable for human workers. Thus, mice are under chronic thermal stress, which can compromise many aspects of physiology from metabolism to pup growth....

  4. Impact of inhalation anaesthesia, surgery and analgesic treatment on home cage behaviour in laboratory mice

    Contributor(s):: Cesarovic, Nikola, Arras, Margarete, Jirkof, Paulin

    Anaesthesia and analgesia are used frequently in laboratory routine to ensure animal welfare and good scientific outcomes in experiments that may elicit pain or require immobilisation of the animal. However, there is concern regarding the effect of these procedures on animal behaviour in...

  5. Housing of female mice in a new environment and its influence on post-surgical behaviour and recovery

    Contributor(s):: Jirkof, Paulin, Cesarovic, Nikola, Rettich, Andreas, Arras, Margarete

    The transportation of mice into a new clean cage after surgery is a standard procedure but might have detrimental effects during the critical post-surgical recovery phase. To analyse the effect of post-surgical housing, female C57BL/6J mice housed in their familiar home cage or in a new...

  6. Critical care and survival of fragile animals: The case of Prrxl1 knockout mice

    Contributor(s):: Monteiro, Clara, Dourado, Margarida, Matos, Mariana, Duarte, Isabel, Lamas, Sofia, Galhardo, Vasco, Lima, Deolinda

    The generation of genetically modified animal models in which a given gene is permanently deleted or overexpressed, sometimes results in fragile phenotypes characterized by high morbidity and premature death. This undesired outcome creates important welfare difficulties and poses a huge...

  7. Variation in stress reactivity affects cage-induced stereotypies in female CD-1 (ICR) mice

    Contributor(s):: Engel, Anna Katarina J., Gross, Alexandra N., Richter, S. Helene, Rommen, Jonas, Touma, Chadi, Würbel, Hanno

    Stereotypies in captive animals typically occur under conditions that are stressful for the animals, and there is some anecdotal evidence that stress levels during early stereotypy development predict later stereotypy levels. Based on this and on the involvement of stress in the behavioural...

  8. Simply a nest? Effects of different enrichments on stereotypic and anxiety-related behaviour in mice

    Contributor(s):: Gross, Alexandra Nam-Mi, Engel, Anna Katarina Julia, Würbel, Hanno

    Improving the home cages of laboratory mice by environmental enrichment has been widely used to reduce cage stereotypies and anxiety-related behaviour in behavioural tests. However, enrichment studies differ substantially in type, complexity and variation of enrichments. Therefore, it is unclear...

  9. A comparison of a manual and an automated behavioural analysis method for assessing post-operative pain in mice

    Contributor(s):: Miller, Amy L., Flecknell, Paul A., Leach, Matthew C., Roughan, John V.

    Current methods of identifying and analysing behavioural signs of pain in mice are highly time consuming and labour intensive. HomeCageScan (HCS) is an automated analysis system that may offer an alternative to manual scoring. Thirty-two male mice undergoing vasectomy were filmed before and at 1h...

  10. Clustered environmental enrichments induce more aggression and stereotypic behaviour than do dispersed enrichments in female mice

    Contributor(s):: Akre, Anne Kathrine, Bakken, Morten, Hovland, Anne Lene, Palme, Rupert, Mason, Georgia

    Adding environmental enrichments to a previously resource-poor cage or enclosure can sometimes cause elevated aggression in socially housed animals, due to competition over the provided resources. Here, using female C57BL/6J mice, we investigated whether the way that environmental enrichments are...

  11. The inescapable problem of lab animal restraint | Garet Lahvis | TEDxMtHood

    Full-text: Available

    | Contributor(s):: Garet Lahvis

      Garet Lahvis is a pioneer in academic research on the mental experiences of laboratory mice and is an internationally recognized scientific expert on empathy. Using sophisticated behavioral experiments, his laboratory discovered that mice enjoy living with other mice and they can also...

  12. The Frequencies of Immunosuppressive Cells in Adipose Tissue Differ in Human, Non-human Primate, and Mouse Models

    | Contributor(s):: Laparra, A., Tricot, S., Le Van, M., Damouche, A., Gorwood, J., Vaslin, B., Favier, B., Benoist, S., Ho Tsong Fang, R., Bosquet, N., Le Grand, R., Chapon, C., Lambotte, O., Bourgeois, C.

  13. Behavioural syndromes in stereotypic striped mice

    | Contributor(s):: Silber, Sarah, Joshi, Sneha, Pillay, Neville

    Stereotypical behaviours (SBs) are abnormal, repetitive behaviours often observed in captivity. SBs are linked to impoverished captive conditions, and stereotypic individuals show a particular set of behaviours (e.g. bolder personality, greater activity) indicating proactive coping. Yet, we do...

  14. Lighting environment: What colour of light do male C57BL/6J prefer?

    | Contributor(s):: Paronis, Efthymios, Kapogiannatou, Aspasia, Paschidis, Konstantinos, Stasinopoulou, Marianna, Alexakos, Pavlos, Skaliora, Irini, Kostomitsopoulos, Nikolaos G.

    Environmental factors applied in animal research facilities need to be regulated accurately not only for the welfare of laboratory animals but also for the reliability of the experimental results. However, the effect of lighting environment and its characteristics on animals has been poorly...

  15. Low welfare impact of noise: assessment in an experimental model of mice infected by Herpes simplex-1

    | Contributor(s):: Trindade Madeira Araújo, Fernanda, Espírito Santo, Lilia de Cássia, Peixoto Teixeira, Ana Carolina, Senra Santos, Beatriz, Galvão Filho, Bruno, Souza Silva, Thais, Duarte, Marina Henriques Lage, da Silva Vasconcellos, Angélica, Farias de Alvarenga, Kevin Augusto, Viana Magno, Luiz Alexandre, Cavalcante, Krisdany Vinícius, Young, Robert John, Campos, Marco Antônio

    The breeding practices adopted and the equipment typically found in animal facilities produce sounds at frequencies within the auditory range of the mice (1 to 100 kHz), which can cause hearing and other non-hearing effects. Another aspect that could potentially affects the welfare of...

  16. Mice aversion to sevoflurane, isoflurane and carbon dioxide using an approach-avoidance task

    | Contributor(s):: Guedes, Silvana R., Valentim, Ana M., Antunes, Luis M.

    Euthanasia of laboratory animals is one of the main concerns for animal welfare, especially the use of carbon dioxide (CO2) which has been described to induce aversive-like behaviours. In order to refine mass euthanasia in rodents, this study aims to determine which gas, sevoflurane, isoflurane...

  17. The impact of bedding volumes on laboratory mice

    | Contributor(s):: Freymann, Jennifer, Tsai, Ping-Ping, Stelzer, Helge, Hackbarth, Hansjoachim

    Environmental refinement is considered to be an improvement in housing conditions for laboratory animals. Previous preference tests showed that female BALB/c and C57BL/6 mice prefer deeper bedding in comparison to shallow bedding (Freymann et al., 2015). In order to give a comprehensive insight...

  18. Buprenorphine via drinking water and combined oral-injection protocols for pain relief in mice

    | Contributor(s):: Sauer, Mareike, Fleischmann, Thea, Lipiski, Miriam, Arras, Margarete, Jirkof, Paulin

    Buprenorphine is the opioid analgesic most commonly used in laboratory mice. However, to maintain therapeutically effective serum levels, repeated injections are required. To overcome negative aspects of restraint and injection, oral self-administration is a promising alternative but has been...

  19. Effect of light colour temperature and intensity on τhε behaviour of male C57CL/6J mice

    | Contributor(s):: Kapogiannatou, Aspasia, Paronis, Efthymios, Paschidis, Konstantinos, Polissidis, Alexia, Kostomitsopoulos, Nikolaos G.

    Light is an important environmental factor affecting laboratory animals' well-being but still there is a range of light parameters in animal research facilities that need further study. Behavioural testing was conducted to study the impact of different conditions of light colour temperature and...

  20. He⿿s getting under my skin! Comparing the sensitivity and specificity of dermal vs subcuticular lesions as a measure of aggression in mice

    | Contributor(s):: Gaskill, Brianna N., Stottler, Aurora, Pritchett-Corning, Kathleen R., Wong, Lilian K., Geronimo, Jerome, Garner, Joseph P.

    Aggression is the leading cause of death in young laboratory mice, representing a major welfare issue. Many of the experimental measures used in traditional aggression research, especially those focusing on territorial aggression (e.g., resident/intruder) are poorly suited to examining dominance...