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  1. The basic neuroscience of emotional experiences in mammals: The case of subcortical FEAR circuitry and implications for clinical anxiety

    Contributor(s):: Panksepp, Jaak, Fuchs, Thomas, Iacobucci, Paolo

    Evidence from behavioral neuroscience strongly suggests that the unconditional (innate) capacity to experience fear, along with fear-typical patterns of autonomic and behavioral arousal, arise from specific systems of the brain—the most prominent being a FEAR circuit which courses between the...

  2. Blood collection procedure of laboratory primates: a neglected variable in biomedical research

    Contributor(s):: Reinhardt, V., Reinhardt, A.

    A survey of 75 biomedical articles dealing with stress-dependent blood parameters ni caged primates revealed that the conditions under which blood collection occurred were in most cases described either not at all or so haphazardly that it would be impossible to determine if humane handling...

  3. Measurement of the serotonin 1A receptor availability in patients with schizophrenia during treatment with the antipsychotic medication ziprasidone

    Contributor(s):: Frankle, W. Gordon, Lombardo, Ilise, Kegeles, Lawrence S., Slifstein, Mark, Martin, John H., Huang, Yiyun, Hwang, Dah-Ren, Reich, Elisa, Cangiano, Claudine, Gil, Roberto, Abi-Dargham, Anissa, Laruelle, Marc

  4. Stimulation of serotonin (5-HT) activity reduces spontaneous stereotypies in female but not in male bank voles ( Clethrionomys glareolus ). Stereotyping female voles as a new animal model for human anxiety and mood disorders?

    Contributor(s):: Schoenecker, B., Heller, K. E.

    Spontaneously stereotyping female and male bank voles were injected daily (except on days assigned for monitoring behaviour) during 3 weeks with placebo, the neurolepticum clozapine or the SSRI antidepressant citalopram. Clozapine blocks dopamine (DA) receptors and acts as a partial serotonin...

  5. The involvement of dopamine (DA) and serotonin (5-HT) in stress-induced stereotypies in bank voles ( Clethrionomys glareolus )

    Contributor(s):: Schoenecker, B., Heller, K. E.

    In order to clarify the dependency of stress-induced stereotypies on dopamine (DA) and serotonin (5-HT) functioning, undisturbed and acutely stressed stereotyping bank voles were treated during 3 weeks with the commonly used human atypical neurolepticum clozapine and the SSRI antidepressant...

  6. Effects of diazepam on the behaviour of weaned pigs in three putative models of anxiety

    Contributor(s):: Andersen, I. L., Faerevik, G., Boe, K. E., Janczak, A. M., Bakken, M.

    The present study examined the effects of diazepam (a widely used anxiolytic benzodiazepine) on the behavioural response of pigs to three novel experimental situations used to measure anxiety-related behaviour in rodents. Twelve weaned pigs (two pairs from each of the three litters) were tested...

  7. Responses of tranquilized post-partum ewes to alien lambs

    Contributor(s):: Tomlinson, K. A., Price, E. O., Torell, D. T.

    Eleven ewes whose young had been taken away 48-72 h after parturition, and nine ewes with a lamb of their own, were penned with alien lambs following a single injection of the tranquillizer perphenazine. Seventeen control ewes, including 15 whose only young had been taken away, were also exposed...

  8. Studies of the pharmacological control of drinking in the pig

    Contributor(s):: Stephens, D. B., Sharman, D. F., Ingram, D. L.

  9. Effects of mixing unfamiliar individuals and of azaperone on the social behaviour of finishing pigs

    Contributor(s):: Tan, S. S. L., Shackleton, D. M.

    The effects of mixing unfamiliar individuals were studied on the social behaviour of finishing pigs. The efficacy of the commercial tranquillizer Stresnil (azaperone) was also examined when mixing animals. Mixing pigs from different groups or litters significantly affected their social behaviour,...

  10. Heart rate changes in loose and tethered sows around feeding

    Contributor(s):: Schouten, W. G. P., Rushen, J., Passille, A. M. de

  11. Normal and more highly reactive horses. II. The effect of handling and reserpine on the cardiac response to stimuli

    Contributor(s):: McCann, J. S., Heird, J. C., Bell, R. W., Lutherer, L. O.

    A split-plot experiment evaluated the effect of handling and a tranquillizer, reserpine, on the autonomic heart-rate response of yearling horses to various stimuli. The emotionality levels of 32 Quarter-Horse yearlings were rated by 4 experienced horsemen on a scale from 1 to 4 (1 = most nervous...

  12. Different methods of grouping and their effects on the agonistic behaviour of sows

    Contributor(s):: Csermely, D., Wood-Gush, D. G. M.

  13. Is social stress in pigs a deterimental factor to health and growth that can be avoided by Amperozide treatment

    Contributor(s):: Bjork, A. K. K.

    In Trial 1, 120 6-week-old pigs were used to investigate the effect of amperozide 1mg/kg i.m. and azaperone 2mg/kg on agonistic behaviour and performance. Fighting behaviour was measured by counting bite and slash marks on each pig before mixing and at 8, 26 and 48 h after penning. Each pig was...

  14. The effect of management practices on stress in farmed red deer ( Cervis elaphus ) and its modulation by long-acting neuroleptics: behavioural responses

    Contributor(s):: Diverio, S., Goodard, P. J., Gordon, I. J., Elston, D. A.

    Eighteen red deer hinds were used to study the behavioural responses over a period of 10 weeks to 3 management practices which were expected to cause increasing levels of stress. The practices were herding, herding and handling and herding, handling and a veterinary procedure. One of 3 groups of...

  15. Use of long-acting neuroleptics to reduce the stress response to management practices in red deer

    Contributor(s):: Diverio, S., Goddard, P. J., Gordon, I. J.

    Three groups of 6 adult red deer (Cervus elaphus) hinds were used to determine whether long-acting neuroleptic (LAN) tranquillizers (1 mg/kg perphenazine enanthate (Trilafon) and 1 mg/kg zuclopenthixol acetate (Clopixol)) were able to modify the behavioural and physiological responses of the deer...

  16. Anxiolytic drugs inhibit hyperthermia induced by handling in farmed silver foxes ( Vulpes vulpes )

    Contributor(s):: Moe, R. O., Bakken, M.

    Eighteen silver fox vixens were divided into 3 equal groups and injected i.m with either diazepam (5 mg/kg) or buspirone (10 mg/kg), or sterile saline (control). Foxes were handled before and at 90 min after injection. Rectal temperature (Trec) was measured as an indicator of stress-induced...

  17. Evaluation of the tranquilliser trap device (TTD) for improving the humaneness of dingo trapping

    Contributor(s):: Marks, C. A., Allen, L., Gigliotti, F., Busana, F., Gonzalez, T., Lindeman, M., Fisher, P. M.

    Predation of sheep and cattle by the dingo (Canis lupus dingo) is implicated in significant stock losses throughout much of mainland Australia. Leg-hold traps are commonly used for dingo control and ways are sought to improve the humaneness of these devices. We evaluated the performance of the...

  18. Stress in wild-caught Eurasian otters ( Lutra lutra ): effects of a long-acting neuroleptic and time in captivity

    Contributor(s):: Fernandez-Moran, J., Saavedra, D., Ruiz de la Torre, J. L., Manteca-Vilanova, X.

    As part of a translocation project, 28 Eurasian otters (Lutra lutra) were captured from the wild and transported to the Barcelona Zoo for veterinary evaluation, quarantine and intraperitoneal implantation of telemetry devices. Eleven animals were injected with the long-acting neuroleptic (LAN)...