-
Anti-schistosoma single-domain antibody-nanoparticles conjugate: a novel tool for diagnostic and therapeutic applications
Contributor(s):: Mohaned Abdelazim Sallam
Nanotechnology has enthused excessive expectations in recent years, particularly in the biology and biomedical fields. Carbon-coated metallic nanomagnets reveal significant physicochemical properties, which are referred to as superparamagnetism, that when designed appropriately can be utilized to...
-
Animal Toxins and Human Disease: From Single Component to Venomics, from Biochemical Characterization to Disease mechanisms, from Crude Venom Utilization to Rational Drug Design
Contributor(s):: Qiu-Min Lu, Ren Lai, Yun Zhang
Many animals produced a diversity of venoms and secretions to adapt the changes of environments through the long history of evolution. The components including a large quantity of specific and highly active peptides and proteins have become good research models for protein structure-function and...
-
Animal models of human diseases
Contributor(s):: Lin Xu
The development of efficient ways to predict, prevent, diagnose and treat human diseases is of great interest to human society and is a focus of life science research. It is widely believed that all human diseases may be attributed to the interaction between genetic and environmental risk...
-
Making Lives Easier for Animals in Research Labs: Discussions by the Laboratory Animal Refinement & Enrichment Forum
Contributor(s):: Vera Baumans (editor), Casey Coke (editor), Jennifer Gren (editor), Erik Moreau (editor), David Morton (editor), Emily Patterson-Kane (editor), Annie Reinhardt (editor), Victor Reinhardt (editor), Pascalle Van Loo (editor)
Making Lives Easier for Animals in Research Labs: Discussions by the Laboratory Animal Refinement & Enrichment Forum is a collection of electronic conversations taken from the Animal Welfare Institute's Laboratory Animal Refinement & Enrichment Forum (LAREF). Participants discuss the treatment,...
-
Adoption of Research Animals
Contributor(s):: Larry Carbone
Estimates of actual numbers of research animals used in the country vary, but one thing is obvious to most of us working in research facilities: the vast majority of these animals are euthanized when their usefulness has ended. Euthanasia is intrinsic to some projects. For example, many projects,...
-
JTT-130, a microsomal triglyceride transfer protein (MTP) inhibitor lowers plasma triglycerides and LDL cholesterol concentrations without increasing hepatic triglycerides in guinea pigs
Contributor(s):: Dimple Aggarwal, Kristy L West, Tosca L Zern, Sudeep Shrestha, Marcela Vergara-Jimenez, Maria Luz Fernandez
Microsomal transfer protein inhibitors (MTPi) have the potential to be used as a drug to lower plasma lipids, mainly plasma triglycerides (TG). However, studies with animal models have indicated that MTPi treatment results in the accumulation of hepatic TG. The purpose of this study was to...
-
Antimicrobial drug consumption in companion animals
Contributor(s):: Ole E. Heuer, Vibeke Frøkjær Jensen, Anette M. Hammerum
During the last decade, use of antimicrobial drugs for growth promotion and therapeutic treatment in food animals has received much attention. The reservoir of resistant bacteria in food animals implies a potential risk for transfer of resistant bacteria, or resistance genes, from food animals to...
-
The ethics of animal research. Talking Point on the use of animals in scientific research
Contributor(s):: Simon Festing, Robin Wilkinson
Animal research has had a vital role in many scientific and medical advances of the past century and continues to aid our understanding of various diseases. Throughout the world, people enjoy a better quality of life because of these advances, and the subsequent development of new medicines and...
-
One health one medicine one world: Co-joint of animal and human medicine with perspectives, a review
| Contributor(s):: C Mersha, F Tewodros, Anjum Sherasiya (editor)
Human and veterinary medicine have many commonalities. The split into distinct disciplines occurred at different times in different places. In Europe, the establishment of the first veterinary university toward the end of 18th century was triggered by ravaging renderpest epidemics and the...
-
Reliability of protocol reviews for animal research
| Contributor(s):: Scott Plous, Harold Herzog
Over the past 20 years, the reliability of scientific peer-review judgments has been a topic of frequent debate and scrutiny. However, one area of peer review that has not received much empirical investigation is the system that protects animal subjects from research risks. At most research...
