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  1. Antimony: The Use, Rights, and Regulation of Laboratory Animals

    Contributor(s):: Brenda L. Thomas

    'In recent years, the problem, plight, and philosophy behind the use of animals in laboratories, schools, and industries has caused many to formulate an opinion on animal experimentation. It is simple to postulate a Monday morning quarterback philosophy - merely weigh the...

  2. Influence of pet ownership on opinions towards the use of animals in biomedical research

    Contributor(s):: Hagelin, J., Johansson, B., Hau, J., Carlsson, H. E.

    The present study investigated the relationship between pet ownership and opinions on the use of animals in medical research. A questionnaire was answered by 484 schoolteacher students and 156 preschool teacher students from Uppsala University, Sweden [date not given]. Animal use was found to be...

  3. A study of three IACUCs and their views of scientific merit and alternatives

    Contributor(s):: Graham, K.

    Two ethical issues facing Institutional Animal Care and Use Committees (IACUCs) today are assessing scientific merit and the use of alternatives in research proposals. This study evaluated 3 IACUCs using a 19-question survey, with a 77.8% response rate. Although 76% of members answered that...

  4. A tail of two monkeys: social housing for nonhuman primates in the research laboratory setting

    Contributor(s):: Seelig, D.

    Despite great adaptability, most nonhuman primates require regular tactile contact with conspecifics for their psychological well being. By illustrating the inherent value of social contact and by providing clues to the best ways of satisfying this need, behavioral studies are useful in designing...

  5. Animal experimentation in cancer research: a citation analysis

    Contributor(s):: Dagg, A. I.

    Cancer research involves the use of millions of nonhuman animals and billions of dollars in public funds each year, but cures for the disease remain elusive. This article suggests ways to reduce the use of animals and save money by identifying articles that garnered few citations over the 9 years...

  6. Artificial weaning of Old World monkeys: benefits and costs

    Contributor(s):: Reinhardt, V.

    Permanent mother-infant separation prior to natural weaning is a common husbandry practice in monkey breeding colonies. In the United States, all eight Regional Primate Research Centres have such colonies. Under undisturbed conditions, Old World monkey mothers wean their infants at the age of...

  7. Behavioral and hormonal consequences of transporting giant pandas from China to the United States

    Contributor(s):: Snyder, R. J., Perdue, B. M., Powell, D. M., Forthman, D. L., Bloomsmith, M. A., Maple, T. L.

    Zoological institutions strive to ensure the welfare of nonhuman animals in captivity. Part of this effort involves reducing the level of distress experienced by an animal to the greatest extent possible. However, some necessary zoo management practices such as transportation induce stress...

  8. Cage size preference in rats in the laboratory

    Contributor(s):: Patterson-Kane, E. G.

    The size of an enclosure is an integral part of how well it accommodates a nonhuman animal's welfare; however, most enrichment studies concentrate on modifying the area inside the enclosure rather than enlarging it. It has been suggested that rats have little need for more cage space, but there...

  9. Combination therapy reduces self-injurious behavior in a chimpanzee ( Pan troglodytes troglodytes ): a case report

    Contributor(s):: Bourgeois, S. R., Vazquez, M., Brasky, K.

    Self-injurious behavior (SIB) remains a severe and intractable abnormal behavior for nonhuman primates in diverse settings and is a significant concern for veterinarians and behavioral scientists. To date, no single pharmacological, behavioral, social, or environmental intervention method has...

  10. Compassion for animals in the laboratory: impairment or refinement of research methodology?

    Contributor(s):: Reinhardt, V.

    There are now signs in the United States as well as in Europe that the importance of a positive human-nonhuman animal relationship in research laboratories is appreciated more seriously. In addition to knowledge and skills, primary attributes of animal research personnel must be feelings of...

  11. Do audible and ultrasonic sounds of intensities common in animal facilities affect the autonomic nervous system of rodents?

    Contributor(s):: Burwell, A. K., Baldwin, A. L.

    In animal facilities, noises, often poorly controlled, occur over a wide range of frequencies and intensities. Evidence demonstrates that audible noise and ultrasound have deleterious effects on rodent physiology, but it is not known how they affect the autonomic nervous system (ANS). This study...

  12. Effects of environmental enrichment for mice: variation in experimental results

    Contributor(s):: Weerd, H. A. van de, Aarsen, E. L., Mulder, A., Kruitwagen, C. L. J. J., Hendriksen, C. F. M., Baumans, V.

    This study focused on the effects of different enriched environments for mice in a number of behavioural and physiological parameters in 2 routine laboratory testing procedures: potency testing for tetanus vaccine and stress-induced hyperthermia. The variability in the results was studied by...

  13. Environmental enrichment alters the behavioral profile of ratsnakes ( Elaphe )

    Contributor(s):: Almli, L. M., Burghardt, G. M.

    This study investigated the effects of environmentally enriched and standard laboratory housing conditions on behavioral performance in 16 subadult ratsnakes (Elaphe obsoleta) using a split-clutch design. In a problem-solving task, snakes housed in enriched environments (EC) exhibited shorter...

  14. Flaws in federal regulations pertaining to the welfare of primates kept in research institutions

    Contributor(s):: Reinhardt, V.

    Federal welfare regulations for primates kept in research laboratories fail to (a) include recommendations pertaining to the legal requirement of the avoidance of stress and unnecessary discomfort during handling procedures, (b) specify how the legally required "uniform illumination" can be...

  15. Genetic engineering and other factors that might affect human-animal interactions in the research setting

    Contributor(s):: Comber, J., Griffin, G.

    Evidence exists, particularly in the welfare literature of nonhuman animals on the farm, that the interaction between nonhuman animals and the personnel who care for them can have a strong effect on the animals' behavior, productivity, and welfare. Among species commonly used for biomedical...

  16. Genetically modified laboratory animals - what welfare problems do they face?

    Contributor(s):: Buehr, M., Hjorth, P. J., Hansen, A. K., Sandoe, P.

    In this article, we respond to public concern expressed about the welfare of genetically modified (GM) non-human animals. As a contribution to the debate on this subject, we attempt in this article to determine in what situations the practice of genetic modification in rodents may generate...

  17. Global harmonization of pain and distress classification systems: current analysis and opportunity for change

    Contributor(s):: Purves, K. E.

    When humans suffer pain or distress, they are generally able to describe their experience to others, including doctors. Medical professionals are also able to convey the likelihood of pain and distress to humans who are voluntarily participating in clinical research trials. The same is not true...

  18. Legal loophole for subminimal floor area for caged macaques

    Contributor(s):: Reinhardt, V.

    Macaques are biologically adapted to an arboreal or semiarboreal lifestyle. They spend much or most of the day and all of the night in elevated locations well off the ground as a safeguard against predators including humans. When they are on the ground during an alarming situation, they...

  19. Levels of citation of nonhuman animal studies conducted at a Canadian Research hospital

    Contributor(s):: Dagg, A. I., Seidle, T. K.

    The publication of scientific articles that receive few or no citations raises questions of the appropriate use of resources as well as ethics. In the case of animal research, the ethics issue extends beyond human patients to nonhuman animals, as the research subjects them to pain and, typically,...

  20. Noise exposure, music, and animals in the laboratory: a commentary based on Laboratory Animal Refinement and Enrichment Forum (LAREF) discussions

    Contributor(s):: Patterson-Kane, E. G., Farnworth, M. J.

    The effects of noise, in general, and music, in particular, on the behavior and welfare of animals in the laboratory deserve a great deal of empirical study. However, many laboratories must develop their current practices on the basis of sparse and conflicting data. With this commentary we seek...