Continuous and Real-Time In Vivo Autobioluminescent Imaging in a Mouse Model
Contributor(s):: Yip, D., Kirkpatrick, A., Xu, T., Masi, T., Stephenson, S., Ripp, S., Close, D.
Pharmacological inhibition of histone deacetylase reduces NADPH oxidase expression, oxidative stress and the progression of atherosclerotic lesions in hypercholesterolemic apolipoprotein E-deficient mice; potential implications for human atherosclero
Contributor(s):: Manea, S. A., Vlad, M. L., Fenyo, I. M., Lazar, A. G., Raicu, M., Muresian, H., Simionescu, M., Manea, A.
The ‘Cage Climber’ - A new enrichment for use in large-dimensioned mouse facilities
Contributor(s):: Vogt, Miriam Annika, Mertens, Sinja, Serba, Susanne, Palme, Rupert, Chourbaji, Sabine
Environmental Enrichment has been shown in experimental contexts to have clear and often beneficial effects on animal physiology and behavior. Housing prior to experiments can represent a large proportion of an animal’s living conditions, and improving housing conditions can be seen as...
Transgressive Little Pests: Hiker Descriptions of “Shelter Mice” on the Appalachian Trail
Contributor(s):: Marx, Kate
Running between Springer Mountain in the state of Georgia, and Mount Katahdin in Maine, the Appalachian Trail (AT) is a more than 2,000 mile long “wilderness” corridor in the United States. People aiming to undertake a trek of the entire length of the trail can expect to spend approximately six...
Use of spontaneous behaviour measures to assess pain in laboratory rats and mice: How are we progressing?
Contributor(s):: Whittaker, Alexandra L., Howarth, Gordon S.
The understanding and recognition of pain in laboratory rats and mice has advanced considerably in recent times. However, there is evidence that despite these advances, analgesics are still relatively underutilised in these species. One possible contributing influence to this is the difficulty in...
Responses by wild house mice (Mus musculus) to various stimuli in a novel environment
Contributor(s):: Witmer, Gary W., Snow, Nathan P., Moulton, Rachael S.
House mice (Mus musculus) pose a threat to the native flora and fauna on islands, and can cause significant damage wherever they have been introduced. Methods used to eradicate invasive rodents, like house mice, at high population densities may not be appropriate for intercepting them at lower...
The naked truth: Breeding performance in nude mice with and without nesting material
Contributor(s):: Gaskill, Brianna N., Winnicker, Christina, Garner, Joseph P., Pritchett-Corning, Kathleen R.
In laboratories, mice are housed at ambient temperatures between 20 and 24°C, which is below their lower critical temperature of 30°C, but comfortable for human workers. Thus, mice are under chronic thermal stress, which can compromise many aspects of physiology from metabolism to pup growth....
Impact of inhalation anaesthesia, surgery and analgesic treatment on home cage behaviour in laboratory mice
Contributor(s):: Cesarovic, Nikola, Arras, Margarete, Jirkof, Paulin
Anaesthesia and analgesia are used frequently in laboratory routine to ensure animal welfare and good scientific outcomes in experiments that may elicit pain or require immobilisation of the animal. However, there is concern regarding the effect of these procedures on animal behaviour in...
Housing of female mice in a new environment and its influence on post-surgical behaviour and recovery
Contributor(s):: Jirkof, Paulin, Cesarovic, Nikola, Rettich, Andreas, Arras, Margarete
The transportation of mice into a new clean cage after surgery is a standard procedure but might have detrimental effects during the critical post-surgical recovery phase. To analyse the effect of post-surgical housing, female C57BL/6J mice housed in their familiar home cage or in a new...
Critical care and survival of fragile animals: The case of Prrxl1 knockout mice
Contributor(s):: Monteiro, Clara, Dourado, Margarida, Matos, Mariana, Duarte, Isabel, Lamas, Sofia, Galhardo, Vasco, Lima, Deolinda
The generation of genetically modified animal models in which a given gene is permanently deleted or overexpressed, sometimes results in fragile phenotypes characterized by high morbidity and premature death. This undesired outcome creates important welfare difficulties and poses a huge...
Variation in stress reactivity affects cage-induced stereotypies in female CD-1 (ICR) mice
Contributor(s):: Engel, Anna Katarina J., Gross, Alexandra N., Richter, S. Helene, Rommen, Jonas, Touma, Chadi, Würbel, Hanno
Stereotypies in captive animals typically occur under conditions that are stressful for the animals, and there is some anecdotal evidence that stress levels during early stereotypy development predict later stereotypy levels. Based on this and on the involvement of stress in the behavioural...
Simply a nest? Effects of different enrichments on stereotypic and anxiety-related behaviour in mice
Contributor(s):: Gross, Alexandra Nam-Mi, Engel, Anna Katarina Julia, Würbel, Hanno
Improving the home cages of laboratory mice by environmental enrichment has been widely used to reduce cage stereotypies and anxiety-related behaviour in behavioural tests. However, enrichment studies differ substantially in type, complexity and variation of enrichments. Therefore, it is unclear...
A comparison of a manual and an automated behavioural analysis method for assessing post-operative pain in mice
Contributor(s):: Miller, Amy L., Flecknell, Paul A., Leach, Matthew C., Roughan, John V.
Current methods of identifying and analysing behavioural signs of pain in mice are highly time consuming and labour intensive. HomeCageScan (HCS) is an automated analysis system that may offer an alternative to manual scoring. Thirty-two male mice undergoing vasectomy were filmed before and at 1h...
Clustered environmental enrichments induce more aggression and stereotypic behaviour than do dispersed enrichments in female mice
Contributor(s):: Akre, Anne Kathrine, Bakken, Morten, Hovland, Anne Lene, Palme, Rupert, Mason, Georgia
Adding environmental enrichments to a previously resource-poor cage or enclosure can sometimes cause elevated aggression in socially housed animals, due to competition over the provided resources. Here, using female C57BL/6J mice, we investigated whether the way that environmental enrichments are...
The inescapable problem of lab animal restraint | Garet Lahvis | TEDxMtHood
| Contributor(s):: Garet Lahvis
Garet Lahvis is a pioneer in academic research on the mental experiences of laboratory mice and is an internationally recognized scientific expert on empathy. Using sophisticated behavioral experiments, his laboratory discovered that mice enjoy living with other mice and they can also...
The Frequencies of Immunosuppressive Cells in Adipose Tissue Differ in Human, Non-human Primate, and Mouse Models
| Contributor(s):: Laparra, A., Tricot, S., Le Van, M., Damouche, A., Gorwood, J., Vaslin, B., Favier, B., Benoist, S., Ho Tsong Fang, R., Bosquet, N., Le Grand, R., Chapon, C., Lambotte, O., Bourgeois, C.
Behavioural syndromes in stereotypic striped mice
| Contributor(s):: Silber, Sarah, Joshi, Sneha, Pillay, Neville
Stereotypical behaviours (SBs) are abnormal, repetitive behaviours often observed in captivity. SBs are linked to impoverished captive conditions, and stereotypic individuals show a particular set of behaviours (e.g. bolder personality, greater activity) indicating proactive coping. Yet, we do...
Lighting environment: What colour of light do male C57BL/6J prefer?
| Contributor(s):: Paronis, Efthymios, Kapogiannatou, Aspasia, Paschidis, Konstantinos, Stasinopoulou, Marianna, Alexakos, Pavlos, Skaliora, Irini, Kostomitsopoulos, Nikolaos G.
Environmental factors applied in animal research facilities need to be regulated accurately not only for the welfare of laboratory animals but also for the reliability of the experimental results. However, the effect of lighting environment and its characteristics on animals has been poorly...
Low welfare impact of noise: assessment in an experimental model of mice infected by Herpes simplex-1
| Contributor(s):: Trindade Madeira Araújo, Fernanda, Espírito Santo, Lilia de Cássia, Peixoto Teixeira, Ana Carolina, Senra Santos, Beatriz, Galvão Filho, Bruno, Souza Silva, Thais, Duarte, Marina Henriques Lage, da Silva Vasconcellos, Angélica, Farias de Alvarenga, Kevin Augusto, Viana Magno, Luiz Alexandre, Cavalcante, Krisdany Vinícius, Young, Robert John, Campos, Marco Antônio
The breeding practices adopted and the equipment typically found in animal facilities produce sounds at frequencies within the auditory range of the mice (1 to 100 kHz), which can cause hearing and other non-hearing effects. Another aspect that could potentially affects the welfare of...
Mice aversion to sevoflurane, isoflurane and carbon dioxide using an approach-avoidance task
| Contributor(s):: Guedes, Silvana R., Valentim, Ana M., Antunes, Luis M.
Euthanasia of laboratory animals is one of the main concerns for animal welfare, especially the use of carbon dioxide (CO2) which has been described to induce aversive-like behaviours. In order to refine mass euthanasia in rodents, this study aims to determine which gas, sevoflurane, isoflurane...